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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: highlight the new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract:

Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 195-203 doi: 10.1007/s11684-012-0189-3

Abstract:

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofenThe anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene.SDBT displayed more significant anti-inflammatory effects than CT.The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea

Keywords： ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

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Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract: view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatoryarticle, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatoryIn summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

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Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 292-301 doi: 10.1007/s11684-020-0806-5

Abstract: However, the role of LMW-HA in inflammatory response is controversial.aimed to investigate the effect of bioactive hyaluronan (B-HA) on lipopolysaccharide (LPS)-induced inflammatorycytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and .In conclusion, our results demonstrated that the B-HA attenuated the LPS-stimulated inflammatory responseB-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease.

Keywords： bioactive hyaluronan     lipopolysaccharide     inflammatory cytokines     TLR4     human macrophages    

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Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic inflammatory

Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie

Strategic Study of CAE 2015, Volume 17, Issue 6,   Pages 4-7

Abstract: insulin-like growth factor-l (IGF-1) and the result of levonorgestrel Intrauterine System Prevention pelvic inflammatoryPatients were followed up for 2Syears to analyse the effluence of pelvic inflammatory disease.Followed up for 2 years, 14 cases has pelvic inflammatory disease in study group,39 cases has pelvicinflammatory disease in control group,there was a significant differences.Conclusions:It may be the mainSmechanism of Prevention pelvic inflammatory disease and inhibition endometrium

Keywords： levonorgestrel     Intrauterine system insulin-like growth factor-1     pelvic inflammatory disease    

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Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

Frontiers of Structural and Civil Engineering 2007, Volume 1, Issue 2,   Pages 129-141 doi: 10.1007/s11709-007-0014-2

Abstract: The assumption and problem of the mode-superposition response spectrum method in seismic design codeThe progresses on the mode superposition response spectrum theory are discussed.multiple-support seismic excitations and deducing corresponding method; 4) the approach for calculation of seismic responseof the non-classically damped system with overcritical damping and the calculation method of seismic response

Keywords： generalization     classical damping     mode-superposition response     calculation formula     damping theory    

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Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 1,   Pages 116-126 doi: 10.1007/s11709-010-0014-5

Abstract: A corresponding computational procedure was compiled and applied in the dynamic response analysis of

Keywords： confining pressure effect     high rockfill dam     dynamic response     Hardin-Drnevich constitutive model    

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Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 3,   Pages 593-606 doi: 10.1007/s11465-021-0636-4

Abstract: method for the continuum topology optimization of transient vibration problem with maximum dynamic responseAn aggregated index in the form of an integral function is presented to cope with the maximum responseThrough comparison with the corresponding static response from the final designs, the optimized results

Keywords： topology optimization     solid isotropic material with penalization     transient response     aggregation function    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Here, we aim to demonstrate that intestinal Axin1 determines gut homeostasis and host response to inflammationAxin1 expression was analyzed in human inflammatory bowel disease datasets.We found increased Axin1 expression in the colonic epithelium of human inflammatory bowel disease (IBDmechanistic studies using specific Axin1 mutations elucidating how Axin1 modulates the microbiome and host inflammatoryresponse will provide new therapeutic strategies for human IBD.

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia    

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Dynamic response of precast segmental bridge columns under heavy truck impact

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 3,   Pages 327-349 doi: 10.1007/s11709-023-0911-z

Abstract: Considering the wide application of precast segmental bridge columns (PSBCs) in engineering practice, impact-resistant performance has gained significant attention. However, few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck collisions. Therefore, the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element (FE) models. The detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental tests. The validated modeling methods were employed to simulate collisions between PSBCs and heavy trucks. The simulation results demonstrated that the engine and cargo caused two major peak impact forces during collision. Subsequently, the impact force, failure mode, displacement, and internal force of the PSBCs under heavy truck impacts were scrutinized. An extensive study was performed to assess the influence of the section size, truck weight, impact velocity, and number of precast segments on the impact responses. The truck weight was found to have a minor effect on the engine impact force. Damage was found to be localized at the bottom of the three segments, with the top remaining primarily undamaged. This parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.

Keywords： precast segmental bridge columns     heavy truck     collision     dynamic response    

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Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 2,   Pages 221-236 doi: 10.1007/s11705-021-2061-y

Abstract: For utilizing such time-resolved data to model the dynamic behavior, dynamic response surface methodology

Keywords： data-driven modeling     pharmaceutical organic synthesis     Lasso regression     dynamic response surface methodology    

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Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 232-251 doi: 10.1007/s11684-020-0797-2

Abstract: In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory

Keywords： non-human primates (rhesus macaques)     myeloid-derived pro-inflammatory cells (MDPCs)     autoimmune disorders    

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Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

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Applications of thermostatically controlled loads for demand response with the proliferation of variable

Meng SONG, Wei SUN

Frontiers in Energy 2022, Volume 16, Issue 1,   Pages 64-73 doi: 10.1007/s11708-021-0732-5

Abstract: (TCLs) attract tremendous attentions because of their specific thermal inertia capability in demand responseSpecifically, intermediate coordinators get the access to fundamental models and response modes of TCLsprograms based on the current research have been reviewed and compared, including fundamental models, response

Keywords： thermostatically controlled load     demand response     renewable energy     power system operation    

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Title Author Date Type Operation

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

Liyuan Chen, Qifeng Dang, Chengsheng Liu, Jun Chen, Lei Song, Xiguang Chen

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Bioactive hyaluronic acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Journal Article

Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic inflammatory

Wu Xiaojie,Liu Xia,Tao Yueping,Wang Jie

Journal Article

Development of a seismic design method based on response spectra for building structures

ZHOU Xiyuan, YU Ruifang

Journal Article

Confining pressure effect on dynamic response of high rockfill dam

Xuexing CAO, Yunlong HE, Kun XIONG,

Journal Article

Topology optimization of transient problem with maximum dynamic response constraint using SOAR scheme

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Dynamic response of precast segmental bridge columns under heavy truck impact

Journal Article

Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis

Journal Article

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Applications of thermostatically controlled loads for demand response with the proliferation of variable

Meng SONG, Wei SUN

Journal Article